TRIM39-RPP21

Across TCGA cell cohorts, TRIM39-RPP21 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TRIM39-RPP21-associated genes across cancer lineages are H1-8, OR8K3, and LIM2. Each is linked with TRIM39-RPP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM39-RPP21-to-partner and partner-to-TRIM39-RPP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-8 grouped by TRIM39-RPP21-low versus TRIM39-RPP21-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM39-RPP21→partner) and Y-score (partner→TRIM39-RPP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H1-8 →	+0.030	+6.357	<.001	<.001	3	1
CNS	OR8K3 →	+0.006	+5.754	.002	.002	3	1
LUNG_NSCLC_LUAD	LIM2 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10R2 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.055	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP10-5 →	+0.019	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

H1-8 by TRIM39-RPP21 expression — CNS

Explore this box plot interactively →