TRIM36

Across TCGA pan-cancer cohorts, TRIM36 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRIM36’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TRIM36 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TRIM36 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, LUAD, and PDAC are the cancer types where TRIM36 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM36 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.548	<.001	7	view →
LUAD	Female	III,IV	+0.368	.045	1	view →
PDAC	Male	II,III,IV	−0.324	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TRIM36–LSCC

Open the LSCC breakdown →