TRIM36

Across TCGA pan-cancer cohorts, TRIM36 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRIM36 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TRIM36 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM36 expression acts as an unfavorable survival marker, although some lineages such as LAML and STAD show a favorable association.

BLCA, UVM, and KIRC are the cancer types where TRIM36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.422	0.604	<.001	108	view →
UVM	DFS	Tertile	II,III,IV	0.368	0.731	<.001	97	view →
KIRC	DFS	Tertile	All	0.549	0.714	<.001	64	view →
MESO	DFS	Median	IV	0.189	0.521	.002	64	view →
KICH	OS	Quartile	II,III,IV	0.511	1.000	.003	56	view →
KIRP	DFS	Quartile	II,III,IV	0.584	0.867	.004	54	view →
LIHC	OS	Median	All	0.426	0.670	<.001	44	view →
LGG	OS	Tertile	All	0.714	0.863	<.001	31	view →
LAML	DFS	Quartile	All	0.721	0.474	.009	24	view →
HNSC	OS	Tertile	IV	0.487	0.818	.011	23	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
SARC	DFS	Tertile	All	0.226	0.435	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRIM36–BLCA (DFS)

Open the BLCA breakdown →