TRIM36

Across TCGA patient cohorts, TRIM36 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM36-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Src_pY527. Each is linked with TRIM36 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM36-to-partner and partner-to-TRIM36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TRIM36-low versus TRIM36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM36→partner) and Y-score (partner→TRIM36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.129	-1.794	.010	.024	3	3
UCEC	PCNA →	+0.258	+2.137	<.001	.001	3	3
UCEC	Src_pY527 →	-0.336	-1.574	.022	.034	3	3
UCEC	Notch1 →	+0.134	+2.125	.005	.010	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.505	-1.794	<.001	.004	3	2
UCEC	p62 Lck ligand →	+0.293	+2.331	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

mTOR_pS2448 by TRIM36 expression — UCEC

Explore this box plot interactively →