TRIM32

Across TCGA patient cohorts, TRIM32 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM32-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and eIF4E. Each is linked with TRIM32 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM32-to-partner and partner-to-TRIM32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TRIM32-low versus TRIM32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM32→partner) and Y-score (partner→TRIM32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.449	+2.169	.004	.002	3	3
UCEC	EGFR_pY1068 →	-0.161	-1.184	.031	.022	3	2
COAD	eIF4E →	+0.238	+3.012	.004	.018	3	2
UCEC	JNK2 →	+0.145	+1.727	.014	.023	3	2
UCEC	Rad50 →	-0.148	-1.184	.040	.022	3	2
UCEC	ATM →	-0.290	-1.184	.032	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Annexin-1 by TRIM32 expression — UCEC

Explore this box plot interactively →