TRIM32

Across TCGA pan-cancer cohorts, TRIM32 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRIM32 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TRIM32 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM32 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

ACC, KIRC, and HNSC are the cancer types where TRIM32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.189	0.705	<.001	118	view →
KIRC	DFS	Tertile	All	0.746	0.524	<.001	78	view →
HNSC	OS	Median	III,IV	0.417	0.698	.002	73	view →
LIHC	DFS	Tertile	All	0.343	0.517	<.001	59	view →
MESO	OS	Quartile	All	0.391	0.666	.001	55	view →
CESC	DFS	Median	All	0.765	0.875	<.001	52	view →
LAML	DFS	Tertile	All	0.203	0.515	<.001	46	view →
COAD	DFS	Median	IV	0.347	0.632	.009	25	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	24	view →
UVM	DFS	Tertile	All	0.435	0.763	.003	21	view →
LUSC	DFS	Quartile	III,IV	0.253	0.628	.002	19	view →
PAAD	OS	Median	All	0.536	0.730	.013	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRIM32–ACC (DFS)

Open the ACC breakdown →