TRIM28

Across TCGA patient cohorts, TRIM28 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM28-associated genes across cancer lineages are JNK2, ERK2, and PCNA. Each is linked with TRIM28 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM28-to-partner and partner-to-TRIM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TRIM28-low versus TRIM28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM28→partner) and Y-score (partner→TRIM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.266	+2.321	<.001	.001	3	3
UCEC	ERK2 →	+0.158	+1.874	.022	.049	3	2
UCEC	PCNA →	+0.167	+2.321	.032	.033	3	2
UCEC	4E-BP1 →	+0.258	+2.614	.008	.005	3	2
UCEC	EGFR_pY1068 →	-0.210	-3.584	.020	.002	3	1
UCEC	eIF4E →	+0.177	+2.700	.020	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

JNK2 by TRIM28 expression — UCEC

Explore this box plot interactively →