TRIM28

Across TCGA pan-cancer cohorts, TRIM28 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRIM28 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TRIM28 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM28 expression acts as an unfavorable survival marker, although some lineages such as UVM and SCLC show a favorable association.

MESO, ACC, and LIHC are the cancer types where TRIM28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.378	0.702	<.001	162	view →
ACC	DFS	Median	All	0.219	0.678	<.001	127	view →
LIHC	OS	Tertile	All	0.540	0.775	<.001	101	view →
UVM	DFS	Median	III,IV	0.877	0.450	.001	68	view →
LUAD	OS	Median	All	0.282	0.424	<.001	65	view →
KIRP	OS	Tertile	All	0.562	0.957	.004	54	view →
SCLC	DFS	Median	III,IV	0.708	0.357	.004	43	view →
SKCM	OS	Median	All	0.277	0.416	<.001	41	view →
UCEC	DFS	Quartile	III,IV	0.912	0.724	<.001	38	view →
LGG	DFS	Tertile	All	0.326	0.520	<.001	37	view →
THYM	OS	Median	All	1.000	0.758	.002	17	view →
LUSC	OS	Tertile	III,IV	0.546	0.752	.018	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRIM28–MESO (OS)

Open the MESO breakdown →