TRIM28

Across TCGA cell cohorts, TRIM28 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,121 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM28-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Mitotic DNA replication, and Regulation of DNA-templated DNA replication. Each is linked with TRIM28 in more than 19 cancer types. Because this analysis shows association rather than direction, both TRIM28-to-partner and partner-to-TRIM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by TRIM28-low versus TRIM28-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM28→partner) and Y-score (partner→TRIM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation involved in DNA replication →	+0.239	+1.284	<.001	<.001	3	20
BONE	Mitotic DNA replication →	+0.239	+1.331	.001	<.001	3	18
BONE	Regulation of DNA-templated DNA replication →	+0.145	+1.378	.002	<.001	3	17
BONE	U2-type prespliceosome assembly →	+0.148	+1.297	<.001	<.001	3	17
SOFT_TISSUE	Protein-DNA complex disassembly →	+0.158	+1.096	<.001	<.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.098	+1.311	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,121 associations by consensus.

DNA strand elongation involved in DNA replication by TRIM28 expression — BONE

Explore this box plot interactively →