TRIM28

Across TCGA cell cohorts, TRIM28 mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM28-associated genes across cancer lineages are IRF2BP1, NUDT6, and SRI. Each is linked with TRIM28 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM28-to-partner and partner-to-TRIM28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRF2BP1 grouped by TRIM28-low versus TRIM28-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM28→partner) and Y-score (partner→TRIM28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRF2BP1 →	+0.634	+3.228	.002	.004	3	2
LARGE_INTESTINE	NUDT6 →	+0.895	+3.082	.001	.007	3	2
LARGE_INTESTINE	SRI →	+1.227	+3.064	<.001	.009	3	2
URINARY_TRACT	AKAP4 →	+0.036	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

IRF2BP1 by TRIM28 expression — BLOOD_Leukemia

Explore this box plot interactively →