TRIM25

Across TCGA patient cohorts, TRIM25 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,968 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TRIM25-associated proteins across cancer lineages are EIF2AK2, MX1, and CMPK2. Each is linked with TRIM25 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRIM25-to-partner and partner-to-TRIM25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRIM25 versus EIF2AK2 in HNSC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM25→partner) and Y-score (partner→TRIM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF2AK2 →	+0.338	+0.574	<.001	.001	3	6
LSCC	MX1 →	+0.959	+0.424	.001	.002	3	6
HNSC	CMPK2 →	+0.585	+0.460	<.001	<.001	3	5
PDAC	HERC6 →	+0.819	+0.395	.007	.005	3	5
HNSC	IFI35 →	+0.384	+0.410	.001	.002	3	5
GBM	IFI44 →	+1.057	+0.450	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,968 associations by consensus.

TRIM25 vs EIF2AK2 — HNSC

Explore this scatter interactively →