TRIM25

Across TCGA pan-cancer cohorts, TRIM25 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRIM25 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRIM25 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM25 expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

CESC, LIHC, and STAD are the cancer types where TRIM25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.635	0.836	<.001	68	view →
LIHC	OS	Tertile	All	0.667	0.834	<.001	58	view →
STAD	OS	Quartile	All	0.590	0.387	.007	51	view →
ACC	OS	Tertile	II,III,IV	0.644	1.000	.005	41	view →
KIRP	DFS	Quartile	III,IV	0.160	0.721	<.001	38	view →
KIRC	DFS	Median	III,IV	0.532	0.744	.002	34	view →
KICH	OS	Quartile	All	0.544	1.000	.005	33	view →
LUAD	DFS	Quartile	IV	0.578	0.951	.012	30	view →
LGG	OS	Median	All	0.855	0.936	<.001	23	view →
UVM	DFS	Quartile	II,III,IV	0.291	0.645	.006	21	view →
HNSC	OS	Tertile	All	0.560	0.340	.007	18	view →
DLBC	DFS	Quartile	All	0.438	1.000	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRIM25–CESC (DFS)

Open the CESC breakdown →