TRIM25

Across TCGA patient cohorts, TRIM25 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM25-associated genes across cancer lineages are MEK1, INPP4B, and JNK2. Each is linked with TRIM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM25-to-partner and partner-to-TRIM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TRIM25-low versus TRIM25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM25→partner) and Y-score (partner→TRIM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.422	+2.807	.008	.003	3	2
UCEC	INPP4B →	-0.316	-3.169	.025	.018	3	1
UCEC	JNK2 →	+0.247	+2.115	.004	.019	3	1
UCEC	Ku80 →	+0.256	+2.820	.013	.001	3	1
UCEC	Notch1 →	+0.176	+2.115	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.356	+2.179	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by TRIM25 expression — UCEC

Explore this box plot interactively →