TRIM25

Across TCGA cell cohorts, TRIM25 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,869 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TRIM25-associated GO terms across cancer lineages are Regulation of autophagosome maturation, Intracellular receptor signaling pathway, and Regulation of pattern recognition receptor signaling pathway. Each is linked with TRIM25 in more than 11 cancer types. Because this analysis shows association rather than direction, both TRIM25-to-partner and partner-to-TRIM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of autophagosome maturation grouped by TRIM25-low versus TRIM25-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM25→partner) and Y-score (partner→TRIM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of autophagosome maturation →	+0.098	+1.543	<.001	<.001	3	12
OESOPHAGUS	Intracellular receptor signaling pathway →	+0.068	+1.062	.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.067	+1.174	.004	.001	3	12
KIDNEY	Regulation of type I interferon-mediated signaling pathway →	+0.137	+1.161	.001	.008	3	11
BLOOD_Lymphoma	Protein poly-ADP-ribosylation →	+0.135	+1.164	<.001	.003	3	11
CNS	Mitotic centrosome separation →	+0.177	+1.484	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,869 associations by consensus.

Regulation of autophagosome maturation by TRIM25 expression — BLOOD_Lymphoma

Explore this box plot interactively →