TRIM25

Across TCGA cell cohorts, TRIM25 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM25-associated genes across cancer lineages are OR14A2, FAM71A, and DEFA4. Each is linked with TRIM25 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM25-to-partner and partner-to-TRIM25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A2 grouped by TRIM25-low versus TRIM25-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM25→partner) and Y-score (partner→TRIM25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR14A2 →	+0.035	+5.169	<.001	.005	3	1
LARGE_INTESTINE	FAM71A →	+0.054	+3.453	.004	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR14A2 by TRIM25 expression — BREAST

Explore this box plot interactively →