TRIM22

Across TCGA cell cohorts, TRIM22 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TRIM22-associated genes across cancer lineages are RLN3, C16orf82, and TNP1. Each is linked with TRIM22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM22-to-partner and partner-to-TRIM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RLN3 grouped by TRIM22-low versus TRIM22-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM22→partner) and Y-score (partner→TRIM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	2
LUNG_NSCLC_LUAD	C16orf82 →	+0.009	+4.662	<.001	.005	3	2
SOFT_TISSUE	TNP1 →	+1.481	+5.369	<.001	.004	3	1
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.028	+5.369	<.001	.004	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RLN3 by TRIM22 expression — SOFT_TISSUE

Explore this box plot interactively →