TRIM15

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRIM15 mutation is significantly associated with the RNA expression of many other genes, with 3,479 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM15-associated genes across cancer lineages are SBF1, CGRRF1, and SRP54. Each is linked with TRIM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM15-to-partner and partner-to-TRIM15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM15→partner) and Y-score (partner→TRIM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSBF1 →+0.684+2.606<.001<.00132
UCECCGRRF1 →+0.379+2.584.003.00132
UCECSRP54 →+0.647+3.290<.001<.00132
UCECADNP2 →+0.914+3.732<.001<.00132
UCECUSP14 →+0.528+3.606.001.00132
UCECLACTB →+0.518+3.839<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,479 associations by consensus.

Exploration