Across TCGA pan-cancer cohorts, TRIM10 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM10 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRIM10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, LUSC, and ESCA are the cancer types where TRIM10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.830	.024	24	view →
LUSC	OS	Median	II,III,IV	0.258	0.622	.010	6	view →
ESCA	OS	Median	II,III,IV	0.360	0.706	.023	6	view →
BLCA	OS	Median	IV	0.211	0.602	.009	3	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRIM10 tumor-vs-normal RNA expression · all TRIM10 data types