TRIL

Across TCGA patient cohorts, TRIL protein abundance is significantly associated with the RNA expression of many other genes, with 1,741 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TRIL-associated genes across cancer lineages are METTL25, RFTN2, and EMX2OS. Each is linked with TRIL in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIL-to-partner and partner-to-TRIL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRIL versus METTL25 in GBM, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIL→partner) and Y-score (partner→TRIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	METTL25 →	+0.547	+0.711	<.001	<.001	3	2
GBM	RFTN2 →	+1.066	+0.736	<.001	<.001	3	2
GBM	EMX2OS →	+0.978	+0.511	<.001	.003	3	2
BRCA	RNA5SP309 →	+0.725	+0.595	.002	<.001	3	2
CCRCC	OR51I1 →	+1.082	+0.414	.008	.001	3	2
CCRCC	UBQLN3 →	+0.993	+0.414	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,741 associations by consensus.

TRIL vs METTL25 — GBM

Explore this scatter interactively →