TRIL

Across TCGA pan-cancer cohorts, TRIL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TRIL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TRIL RNA is repressed in tumor relative to normal tissue. In most cancer types TRIL is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LIHC are the cancer types where TRIL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.520	<.001	9	view →
KIRP	Female	All	−1.593	<.001	9	view →
LIHC	Male	All	+0.761	<.001	8	view →
HNSC	Male	II,III,IV	−1.027	.001	6	view →
BLCA	All	All	−0.823	.003	6	view →
UCEC	All	All	−0.829	.006	4	view →
LUSC	All	All	−0.590	.004	4	view →
KIRC	Male	II,III,IV	−0.509	.016	2	view →
LUAD	All	All	−0.456	.023	2	view →
THCA	All	All	+0.363	.005	2	view →
CHOL	All	All	+0.712	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TRIL–KICH

Open the KICH breakdown →