TRIL

Across TCGA patient cohorts, TRIL mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIL-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and EGFR_pY1068. Each is linked with TRIL in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIL-to-partner and partner-to-TRIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TRIL-low versus TRIL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIL→partner) and Y-score (partner→TRIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.139	-2.459	.003	.019	3	2
UCEC	14-3-3_beta →	-0.083	-2.295	.039	.033	3	1
UCEC	EGFR_pY1068 →	-0.208	-1.874	.039	.049	3	1
UCEC	eIF4G →	+0.278	+2.999	.026	.035	3	1
UCEC	ERK2 →	+0.215	+2.584	.005	.010	3	1
UCEC	ACC1 →	+0.348	+1.906	.017	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by TRIL expression — UCEC

Explore this box plot interactively →