TRIB3

Across TCGA pan-cancer cohorts, TRIB3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRIB3 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TRIB3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRIB3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, UCEC, and COAD are the cancer types where TRIB3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	IV	0.028	0.759	.002	12	view →
UCEC	DFS	Median	All	1.000	0.829	.020	8	view →
COAD	DFS	Median	All	0.233	0.793	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TRIB3–OV (OS)

Open the OV breakdown →