TRIB3

Across TCGA pan-cancer cohorts, TRIB3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TRIB3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRIB3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIB3 is over-expressed in tumor.

COAD, KIRC, and HNSC are the cancer types where TRIB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+4.388	<.001	12	view →
KIRC	Male	All	+2.877	<.001	12	view →
HNSC	Male	III,IV	+1.833	<.001	12	view →
KIRP	All	III,IV	+2.546	<.001	10	view →
STAD	Male	III,IV	+3.108	<.001	9	view →
BLCA	Male	III,IV	+2.857	<.001	8	view →
READ	All	II,III,IV	+3.442	<.001	7	view →
LUAD	Male	All	+0.945	<.001	7	view →
KICH	Male	IV	+3.150	.002	6	view →
BRCA	All	III,IV	+1.716	<.001	6	view →
LUSC	Male	II,III,IV	+1.497	<.001	6	view →
UCEC	All	All	+1.341	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TRIB3–COAD

Open the COAD breakdown →