TRIB3

Across TCGA patient cohorts, TRIB3 mutation is significantly associated with the RNA expression of many other genes, with 1,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIB3-associated genes across cancer lineages are SNORD105B, CTXN2, and CCNB2. Each is linked with TRIB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIB3-to-partner and partner-to-TRIB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD105B grouped by TRIB3-low versus TRIB3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB3→partner) and Y-score (partner→TRIB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD105B →	+0.306	+3.007	<.001	.005	3	3
CESC	CTXN2 →	+0.041	+4.601	<.001	.004	3	2
UCEC	CCNB2 →	+0.627	+2.831	.003	.001	3	2
UCEC	URM1 →	+0.365	+3.815	.001	<.001	3	2
UCEC	DAPK3 →	+0.365	+2.593	.008	.006	3	2
UCEC	LRRC34 →	-0.504	-3.490	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

SNORD105B by TRIB3 expression — SKCM

Explore this box plot interactively →