TRIB3

Across TCGA patient cohorts, TRIB3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIB3-associated genes across cancer lineages are PI3K-p110-a, TIGAR, and Caspase-7-cleavedD198. Each is linked with TRIB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIB3-to-partner and partner-to-TRIB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by TRIB3-low versus TRIB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB3→partner) and Y-score (partner→TRIB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p110-a →	-0.143	-3.308	.039	.009	3	2
UCEC	TIGAR →	+0.169	+2.529	.004	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.970	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.102	-1.571	.010	.036	3	1
UCEC	eEF2 →	+0.381	+2.459	.006	.019	3	1
UCEC	EGFR_pY1068 →	-0.323	-2.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PI3K-p110-a by TRIB3 expression — UCEC

Explore this box plot interactively →