TRIB3

Across TCGA cell cohorts, TRIB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,511 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIB3-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, Negative regulation of translation in response to endoplasmic reticulum stress, and L-histidine transport. Each is linked with TRIB3 in more than 16 cancer types. Because this analysis shows association rather than direction, both TRIB3-to-partner and partner-to-TRIB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress grouped by TRIB3-low versus TRIB3-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB3→partner) and Y-score (partner→TRIB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.149	+2.009	<.001	<.001	3	17
BONE	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.209	+1.995	<.001	.002	3	13
KIDNEY	L-histidine transport →	+0.186	+1.661	.001	.001	3	13
BLOOD_Lymphoma	VEGF-activated platelet-derived growth factor receptor signaling pathway →	+0.399	+1.175	<.001	<.001	3	12
BLOOD_Lymphoma	Positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway →	+0.399	+1.175	<.001	<.001	3	12
SKIN	L-alanine catabolic process →	+0.784	+1.152	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,511 associations by consensus.

Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress by TRIB3 expression — BLOOD_Myeloma

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