TRIB3

Across TCGA cell cohorts, TRIB3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIB3-associated genes across cancer lineages are GUCA2A, C16orf92, and P2RY13. Each is linked with TRIB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIB3-to-partner and partner-to-TRIB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by TRIB3-low versus TRIB3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB3→partner) and Y-score (partner→TRIB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GUCA2A →	+0.052	+4.273	.009	.006	3	2
SKIN	C16orf92 →	+0.036	+4.415	<.001	.007	3	1
SKIN	P2RY13 →	+0.006	+4.684	<.001	.002	3	1
SKIN	MYH6 →	+0.019	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	TAS2R8 →	+0.042	+3.793	<.001	.007	3	1
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GUCA2A by TRIB3 expression — SKIN

Explore this box plot interactively →