TRIB2

Across TCGA patient cohorts, TRIB2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIB2-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and STAT3_pY705. Each is linked with TRIB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIB2-to-partner and partner-to-TRIB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIB2-low versus TRIB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB2→partner) and Y-score (partner→TRIB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.492	+1.945	.006	.002	3	3
UCEC	GAPDH →	+0.385	+1.263	.019	.019	3	2
UCEC	STAT3_pY705 →	-0.391	-1.700	<.001	.001	3	2
UCEC	ATM →	-0.435	-2.308	.001	.005	3	2
UCEC	4E-BP1 →	+0.246	+2.700	.003	.005	3	2
UCEC	eEF2 →	+0.326	+1.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by TRIB2 expression — UCEC

Explore this box plot interactively →