TRIB2

Across TCGA pan-cancer cohorts, TRIB2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TRIB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TRIB2 RNA is repressed in tumor relative to normal tissue. In most cancer types TRIB2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LIHC are the cancer types where TRIB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.390	<.001	11	view →
KIRP	Male	II,III,IV	−1.887	<.001	9	view →
LIHC	All	II,III,IV	+1.568	<.001	9	view →
HNSC	All	All	+0.665	<.001	9	view →
STAD	Male	II,III,IV	+1.721	<.001	6	view →
CHOL	Female	All	+2.516	<.001	5	view →
THCA	All	All	+0.443	<.001	5	view →
UCEC	All	All	−1.276	.001	2	view →
KIRC	Male	III,IV	−0.450	.029	2	view →
COAD	All	All	+0.399	.020	2	view →
BLCA	Female	IV	−1.293	.043	1	view →
KIRC	Female	All	+0.505	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

TRIB2–KICH

Open the KICH breakdown →