TRIB2

Across TCGA cell cohorts, TRIB2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIB2-associated genes across cancer lineages are OR13C4, PRR23C, and SLC39A14. Each is linked with TRIB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIB2-to-partner and partner-to-TRIB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C4 grouped by TRIB2-low versus TRIB2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB2→partner) and Y-score (partner→TRIB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR13C4 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR23C →	+0.006	+5.228	.005	.005	3	1
LARGE_INTESTINE	SLC39A14 →	+0.813	+3.067	.006	.009	3	1
LARGE_INTESTINE	PCCB →	+0.592	+3.125	.004	.008	3	1
LARGE_INTESTINE	ACER1 →	+0.103	+3.408	<.001	<.001	3	1
LARGE_INTESTINE	SARAF →	+0.766	+3.125	.002	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR13C4 by TRIB2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →