TRIB1

Across TCGA patient cohorts, TRIB1 mutation is significantly associated with the RNA expression of many other genes, with 3,693 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIB1-associated genes across cancer lineages are MRPS33P3, LINC01609, and H2AZP7. Each is linked with TRIB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIB1-to-partner and partner-to-TRIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS33P3 grouped by TRIB1-low versus TRIB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB1→partner) and Y-score (partner→TRIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS33P3 →	+0.115	+3.682	<.001	.004	3	1
SKCM	LINC01609 →	+0.076	+4.452	<.001	<.001	3	1
SKCM	H2AZP7 →	+0.121	+3.744	.004	.003	3	1
SKCM	H3P35 →	+0.116	+4.302	<.001	.007	3	1
SKCM	NUTF2P2 →	+0.166	+3.646	.003	.008	3	1
SKCM	NIFKP4 →	+0.043	+3.032	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,693 associations by consensus.

MRPS33P3 by TRIB1 expression — SKCM

Explore this box plot interactively →