TRIB1

Across TCGA pan-cancer cohorts, TRIB1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRIB1 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TRIB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIB1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

UVM, LUSC, and KIRC are the cancer types where TRIB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.411	0.777	<.001	148	view →
LUSC	DFS	Quartile	All	0.276	0.452	<.001	62	view →
KIRC	DFS	Median	IV	0.345	0.678	<.001	60	view →
LGG	OS	Median	All	0.377	0.555	<.001	45	view →
ACC	DFS	Tertile	All	0.359	0.704	.005	43	view →
KIRP	DFS	Median	All	0.457	0.750	.001	40	view →
OV	OS	Median	IV	0.596	0.878	.003	30	view →
BRCA	DFS	Quartile	IV	0.924	0.394	.005	29	view →
PAAD	DFS	Quartile	All	0.167	0.418	.005	21	view →
BLCA	DFS	Median	All	0.693	0.492	.009	18	view →
SCLC	OS	Quartile	All	0.564	0.251	.006	16	view →
KICH	OS	Median	III,IV	1.000	0.792	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRIB1–UVM (OS)

Open the UVM breakdown →