TRIB1

Across TCGA patient cohorts, TRIB1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIB1-associated genes across cancer lineages are A-Raf_pS299, eEF2, and EGFR_pY1068. Each is linked with TRIB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIB1-to-partner and partner-to-TRIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TRIB1-low versus TRIB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB1→partner) and Y-score (partner→TRIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.161	-3.459	<.001	.005	3	2
UCEC	eEF2 →	+0.371	+2.321	.008	.033	3	1
UCEC	EGFR_pY1068 →	-0.281	-2.807	.004	.003	3	1
UCEC	FoxM1 →	+0.258	+3.169	.011	<.001	3	1
UCEC	ACC_pS79 →	+0.370	+2.009	.006	.017	3	1
UCEC	Gab2 →	+0.319	+1.584	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

A-Raf_pS299 by TRIB1 expression — UCEC

Explore this box plot interactively →