TRIB1

Across TCGA cell cohorts, TRIB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,156 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TRIB1-associated GO terms across cancer lineages are Regulation of neutrophil differentiation, Negative regulation of lipopolysaccharide-mediated signaling pathway, and Negative regulation of granulocyte differentiation. Each is linked with TRIB1 in more than 17 cancer types. Because this analysis shows association rather than direction, both TRIB1-to-partner and partner-to-TRIB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of neutrophil differentiation grouped by TRIB1-low versus TRIB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIB1→partner) and Y-score (partner→TRIB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of neutrophil differentiation →	+1.496	+1.660	<.001	<.001	3	18
LIVER	Negative regulation of lipopolysaccharide-mediated signaling pathway →	+0.182	+1.510	.001	.008	3	13
LUNG_SCLC	Negative regulation of granulocyte differentiation →	+0.904	+1.053	<.001	<.001	3	13
LIVER	Positive regulation of granulocyte differentiation →	+0.335	+1.857	<.001	.002	3	12
OVARY	Positive regulation of macrophage differentiation →	+0.148	+1.915	<.001	<.001	3	8
LIVER	Regulation of granulocyte differentiation →	+0.275	+1.535	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,156 associations by consensus.

Regulation of neutrophil differentiation by TRIB1 expression — UPPER_AERODIGESTIVE_TRACT

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