TRHDE

Across TCGA pan-cancer cohorts, TRHDE Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TRHDE data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRHDE Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TRHDE expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, KIRP, and PCPG are the cancer types where TRHDE Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.941	0.466	.005	36	view →
KIRP	OS	Median	All	0.111	0.897	<.001	24	view →
PCPG	OS	Median	All	0.010	0.946	<.001	12	view →
SCLC	OS	Median	II,III,IV	0.205	0.659	.006	12	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	7	view →
SKCM	DFS	Median	IV	1.000	0.240	.020	5	view →
LUAD	OS	Median	All	0.836	0.340	.029	4	view →
LIHC	DFS	Median	II,III,IV	0.044	0.414	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TRHDE–UCEC (DFS)

Open the UCEC breakdown →