TRHDE

Across TCGA pan-cancer cohorts, TRHDE RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRHDE’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRHDE RNA is repressed in tumor relative to normal tissue. In most cancer types TRHDE is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where TRHDE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRHDE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.259	<.001	11	view →
LUAD	Female	II,III,IV	−1.453	<.001	9	view →
BRCA	All	III,IV	−0.935	<.001	8	view →
LUSC	Female	II,III,IV	−1.715	<.001	7	view →
THCA	All	II,III,IV	−0.120	<.001	7	view →
UCEC	All	All	−0.833	<.001	6	view →
READ	All	II,III,IV	−0.805	<.001	6	view →
KIRP	All	III,IV	−1.119	.001	5	view →
HNSC	Male	IV	−0.303	.009	4	view →
PRAD	All	All	−0.659	<.001	2	view →
CHOL	All	II,III,IV	−0.449	<.001	2	view →
LIHC	Female	II,III,IV	+0.437	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRHDE–COAD

Open the COAD breakdown →