TRHDE

Across TCGA patient cohorts, TRHDE mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRHDE-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and eEF2. Each is linked with TRHDE in more than 4 cancer types. Because this analysis shows association rather than direction, both TRHDE-to-partner and partner-to-TRHDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TRHDE-low versus TRHDE-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRHDE→partner) and Y-score (partner→TRHDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.253	+3.342	<.001	.005	2	5
LUSC	EGFR_pY1068 →	+0.337	+2.000	.038	.028	3	4
UCEC	eEF2 →	+0.266	+1.765	.008	.011	3	4
UCEC	GAPDH →	+0.387	+1.440	.011	.020	3	4
UCEC	ASNS →	+0.337	+1.152	.001	.048	3	4
STAD	FoxM1 →	+0.360	+3.031	.003	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

Cyclin-E2 by TRHDE expression — STAD

Explore this box plot interactively →