TRHDE

Across TCGA cell cohorts, TRHDE mutation is significantly associated with the RNA expression of many other genes, with 919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRHDE-associated genes across cancer lineages are PIP, SNTG2, and LEUTX. Each is linked with TRHDE in more than 1 cancer types. Because this analysis shows association rather than direction, both TRHDE-to-partner and partner-to-TRHDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by TRHDE-low versus TRHDE-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRHDE→partner) and Y-score (partner→TRHDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PIP →	+0.198	+3.099	.001	.003	3	2
BLOOD_Lymphoma	SNTG2 →	+1.999	+3.554	<.001	.007	3	2
CNS	LEUTX →	+0.110	+3.584	<.001	.002	3	2
LUNG_SCLC	CDX1 →	+0.052	+3.220	<.001	.002	3	1
LUNG_SCLC	IL2RA →	+0.059	+2.906	<.001	.007	3	1
LUNG_SCLC	C10orf120 →	+0.017	+3.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 919 associations by consensus.

PIP by TRHDE expression — LUNG_SCLC

Explore this box plot interactively →