TRHDE-AS1

Across TCGA pan-cancer cohorts, TRHDE-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRHDE-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher TRHDE-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRHDE-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

UVM, UCEC, and STAD are the cancer types where TRHDE-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.324	0.793	<.001	132	view →
UCEC	OS	Median	All	0.893	0.953	<.001	96	view →
STAD	OS	Median	All	0.480	0.677	<.001	93	view →
LUSC	DFS	Quartile	III,IV	0.421	0.801	<.001	90	view →
KIRC	OS	Tertile	All	0.904	0.811	<.001	77	view →
LGG	DFS	Median	All	0.479	0.332	<.001	51	view →
KIRP	DFS	Median	All	0.938	0.619	.001	44	view →
ACC	OS	Median	All	0.417	0.765	<.001	30	view →
BRCA	OS	Tertile	III,IV	0.704	0.444	.001	26	view →
THCA	OS	Tertile	III,IV	0.726	0.963	.016	18	view →
ESCA	DFS	Quartile	All	0.571	0.352	.014	16	view →
PAAD	DFS	Quartile	All	0.217	0.538	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRHDE-AS1–UVM (DFS)

Open the UVM breakdown →