TRH

Across TCGA patient cohorts, TRH mutation is significantly associated with the RNA expression of many other genes, with 186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRH-associated genes across cancer lineages are HMGB4, RN7SL675P, and RNU6-451P. Each is linked with TRH in more than 1 cancer types. Because this analysis shows association rather than direction, both TRH-to-partner and partner-to-TRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB4 grouped by TRH-low versus TRH-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRH→partner) and Y-score (partner→TRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HMGB4 →	+0.015	+5.306	<.001	.006	3	2
LUSC	RN7SL675P →	+0.082	+4.309	<.001	.007	3	2
UCEC	RNU6-451P →	+0.499	+2.631	<.001	.007	3	2
BLCA	IGHVIII-5-1 →	+0.787	+5.251	<.001	.006	3	1
BLCA	IGHVIII-13-1 →	+0.323	+5.411	<.001	.005	3	1
BLCA	TUBAP7 →	+0.039	+5.177	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

HMGB4 by TRH expression — CESC

Explore this box plot interactively →