Across TCGA patient cohorts, TRGV4 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRGV4-associated genes across cancer lineages are MIR6815, HNRNPCL3, and LINC02559. Each is linked with TRGV4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRGV4-to-partner and partner-to-TRGV4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRGV4→partner) and Y-score (partner→TRGV4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6815 →	+0.275	+4.797	<.001	.003	3	2
UCEC	HNRNPCL3 →	+0.074	+3.778	<.001	.007	3	1
SKCM	LINC02559 →	+0.128	+4.624	<.001	.005	3	1
SKCM	NMBR-AS1 →	+0.148	+4.513	<.001	.001	3	1
SKCM	FAM138A →	+0.018	+5.219	<.001	.002	3	1
SKCM	RN7SL681P →	+0.140	+3.408	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

TRGV4 survival (RNA) · tumor vs normal (RNA) · all TRGV4 data types