Across TCGA pan-cancer cohorts, TRGV4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRGV4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRGV4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRGV4 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where TRGV4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRGV4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.744	<.001	12	view →
COAD	Female	All	−0.780	<.001	8	view →
LUSC	All	All	−0.514	<.001	5	view →
THCA	Female	II,III,IV	−0.279	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRGV4 RNA expression & survival · all TRGV4 data types