TRGV2

Across TCGA patient cohorts, TRGV2 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRGV2-associated genes across cancer lineages are RNU2-15P, ATG4AP1, and RNA5SP258. Each is linked with TRGV2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRGV2-to-partner and partner-to-TRGV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-15P grouped by TRGV2-low versus TRGV2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRGV2→partner) and Y-score (partner→TRGV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU2-15P →	+0.128	+5.219	<.001	.002	3	2
BLCA	ATG4AP1 →	+0.054	+7.640	<.001	.009	3	2
BLCA	RNA5SP258 →	+0.228	+7.640	<.001	.009	3	1
SKCM	JRKL-AS1 →	+0.056	+4.469	<.001	.006	3	1
SKCM	GEMIN8P1 →	+0.060	+3.817	<.001	.004	3	1
SKCM	OR1D5 →	+0.026	+4.469	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

RNU2-15P by TRGV2 expression — SKCM

Explore this box plot interactively →