TRG-AS1

Across TCGA pan-cancer cohorts, TRG-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRG-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRG-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRG-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where TRG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.382	0.255	<.001	114	view →
SKCM	OS	Median	All	0.420	0.256	<.001	81	view →
UVM	DFS	Tertile	II,III,IV	0.406	0.764	<.001	72	view →
BRCA	DFS	Median	All	0.966	0.931	.002	56	view →
LGG	DFS	Median	All	0.312	0.479	<.001	50	view →
ACC	OS	Quartile	II,III,IV	0.698	0.924	.004	41	view →
LUAD	DFS	Median	All	0.724	0.610	.002	41	view →
CESC	DFS	Tertile	All	0.843	0.654	.001	36	view →
KIRP	DFS	Tertile	All	0.494	0.893	.002	34	view →
LIHC	DFS	Median	All	0.381	0.217	.010	30	view →
COAD	DFS	Median	II,III,IV	0.721	0.603	.010	25	view →
SARC	OS	Median	All	0.867	0.652	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRG-AS1–HNSC (DFS)

Open the HNSC breakdown →