Across TCGA patient cohorts, TREX2 mutation is significantly associated with the RNA expression of many other genes, with 2,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREX2-associated genes across cancer lineages are RESP18, MIR154, and RNU6-1277P. Each is linked with TREX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	RESP18 →	+0.158	+3.712	<.001	.009	3	1
HNSC	MIR154 →	+0.388	+7.954	<.001	.008	3	1
BLCA	RNU6-1277P →	+0.425	+5.106	<.001	.008	3	1
UCEC	NUDT3 →	+0.342	+3.470	.004	.002	3	1
UCEC	ZNHIT3 →	+0.412	+2.831	.008	.001	3	1
UCEC	CYFIP1 →	+0.553	+3.345	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types