Across TCGA pan-cancer cohorts, TREX1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated TREX1 data layer compared with 1 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TREX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TREX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where TREX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.756	1.000	.038	18	view →
PDAC	OS	Quartile	All	0.448	0.684	.007	17	view →
HNSC	OS	Median	IV	0.930	0.724	.022	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
CCRCC	OS	Tertile	II,III,IV	0.812	0.501	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TREX1 tumor-vs-normal RNA expression · all TREX1 data types