TRERF1

Across TCGA patient cohorts, TRERF1 mutation is significantly associated with the RNA expression of many other genes, with 4,841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRERF1-associated genes across cancer lineages are SLC20A1, WFDC10B, and TSPY26P. Each is linked with TRERF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRERF1-to-partner and partner-to-TRERF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC20A1 grouped by TRERF1-low versus TRERF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRERF1→partner) and Y-score (partner→TRERF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC20A1 →	+0.383	+2.545	<.001	<.001	3	4
UCEC	WFDC10B →	-0.243	-1.826	.002	.002	3	4
SKCM	TSPY26P →	-0.901	-2.887	<.001	<.001	3	4
UCEC	HOMER1 →	+0.586	+2.044	<.001	<.001	3	3
UCEC	BUB3 →	+0.384	+2.001	<.001	.002	3	3
UCEC	ARPC2 →	+0.351	+3.343	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,841 associations by consensus.

SLC20A1 by TRERF1 expression — UCEC

Explore this box plot interactively →