TRERF1

Across TCGA cell cohorts, TRERF1 mutation is significantly associated with the RNA expression of many other genes, with 969 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRERF1-associated genes across cancer lineages are GRIFIN, KRT28, and SULT1C3. Each is linked with TRERF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRERF1-to-partner and partner-to-TRERF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRIFIN grouped by TRERF1-low versus TRERF1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRERF1→partner) and Y-score (partner→TRERF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GRIFIN →	+0.060	+5.169	<.001	.004	3	2
OVARY	KRT28 →	+0.065	+4.029	<.001	.009	3	2
LUNG_NSCLC_LUAD	SULT1C3 →	+0.037	+3.947	.005	.004	3	2
UPPER_AERODIGESTIVE_TRACT	KCNA3 →	+0.044	+3.807	.007	.005	3	2
UPPER_AERODIGESTIVE_TRACT	WFDC10A →	+0.047	+3.870	<.001	.003	3	2
BLOOD_Leukemia	LRRC23 →	+0.838	+3.259	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 969 associations by consensus.

GRIFIN by TRERF1 expression — BONE

Explore this box plot interactively →