Across TCGA cell cohorts, TREML4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TREML4-associated genes across cancer lineages are PSAPL1, SMIM21, and ZSWIM2. Each is linked with TREML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML4-to-partner and partner-to-TREML4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML4→partner) and Y-score (partner→TREML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSAPL1 →	+0.052	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SMIM21 →	+0.013	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	ZSWIM2 →	+0.032	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TMCO5A →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FAM162B →	+0.158	+4.095	<.001	.009	3	1
LARGE_INTESTINE	PABPC1L2B →	+0.027	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TREML4 survival (RNA) · tumor vs normal (RNA) · all TREML4 data types