Across TCGA cell cohorts, TREML4 mutation is significantly associated with the mutation status of many other genes, with 311 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TREML4-associated genes across cancer lineages are PTCHD1, GFI1B, and ITGB5. Each is linked with TREML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML4-to-partner and partner-to-TREML4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML4→partner) and Y-score (partner→TREML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTCHD1 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	GFI1B →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	ITGB5 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	ZNF334 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	OR51M1 →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	FOXRED2 →	+4.772	+5.339	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

Exploration

TREML4 survival (RNA) · tumor vs normal (RNA) · all TREML4 data types